Clinical onset is usually a pain in the bones and dysfunctions of the nearby joint. In most cases the tumor begins to grow in the lower third of the femur or in the knee joint. In connection with its localization, young people often do not give it the appearance of great importance, copying a probable injury or a minor knee injury. However, the pain of the tumor, unlike those in the bone injury, not subsides at rest. Therefore, patients may indicate that longer notice it at night. Pain syndrome is accompanied by mild fever, general weakness and malaise. With the growth of tumors, symptoms of involvement in the inflammatory process of the nearby joint. The muscles above the compensatory stiff joints, preventing accidental movement in it. The same will be marked reddening of the skin in the projection of the tumor, an increase in local temperature of tissues and the apparent expansion of the cutaneous vessels. Part One of the diagnostic conjecture in these cases is bone fracture, complicated by arthritis or osteomyelitis. In cases where Ewing's sarcoma develops in the ribs, the clinic can simulate such, with pneumonia or pleurisy - chest pain due to which the patient breathes surface, limiting the range of motion of the rib framework with breathing.

The clinical and usually develops within a few weeks to several months. The earliest possible access to a doctor can cure the tumor completely without genital procedures - without the amputation of limbs or parts thereof, or removal of the ribs. Since the time of treatment to the doctor usually gives the tumor metastases, treatment must include chemotherapy. Along with her, hold local treatment of the primary tumor focus - the surgical removal of the tumor and affected bone, followed by local radiotherapy. Duration of treatment depends on the activity of the tumor, the extent of bone and presence of metastases, but for most patients chemotherapy is 6-12 months and postoperative radiotherapy - 1-2 months. The probability of complete recovery for the tumor without metastasis after a full course of treatment 70%, in the case of metastasis prognosis is much worse.

 

For bone sarcomas is characterized by rapid growth and early metastasis. Ewing's sarcoma is the second most common among malignant bone tumors in children - is 10-15%. This tumor is rare in children younger than 5 years and adults older than 30 years. The peak incidence occurs in 10 -15 years.

The cause of malignant bone tumors is not yet known, but it is proved that in 40% of the occurrence of bone sarcoma provoking trauma.

Ewing's sarcoma is composed of small round cells with scanty cytoplasm, round nucleus containing delicate chromatin and weakly observable basophilic nukleoly. In contrast to osteosarcoma, it does not produce osteoid.

The idea of the endothelial nature of Ewing tumors prevailed before 1980. Studies in recent years, showed neurogenic nature of Ewing tumors. Although most Ewing's sarcoma is an undifferentiated tumor of bone, there is evidence of soft tissue lesions (ekstraossalnaya Ewing's sarcoma). In the literature, the term appeared «family of tumors such as Kaposi's sarcoma