• Multicomponent chemotherapy (using drugs - vincristine, adriamycin, ifosfamide, cyclophosphamide, actinomycin, vepezid in combination). In modern treatment programs used preoperative and postoperative polychemotherapy, consideration being given to histological tumor response to treatment. Good tumor response to chemotherapy is the presence of less than 5% of live tumor cells.
• Radiation therapy to the center in high doses. In the development of metastases in the lungs is carried out radiation therapy to the lungs.
• If possible, radical removal of tumor (including bone and soft tissue components). Radical resection is possible with a focus in the fibula, the bones of the forearm, ribs, collarbone, shoulder blade.

The operation improves local control of tumor. In combination with intensive chemotherapy and radiotherapy significantly reduced the risk of local recurrence. Reducing the frequency of local recurrence is noted even after non-radical operation. Modern surgical technology makes it possible to perform organ-operation with lesions of the femur, humerus, and resection of the pelvic bones.

Patients with a poor prognosis, particularly with metastases in bone and bone marrow, with a survival rate of less than 10%, recently appointed a more intensive treatment - chemotherapy drugs megadozami total irradiation of the body and transplantation of autologous bone marrow or peripheral stem cells. This therapy can cure more than 30% of patients with advanced process (with metastases to bone and bone marrow). Patients with a good sensitivity of the tumor can achieve even better results of treatment (7-year survival is around 50%).