what to know about non-Hodgkin's lymphoma
Our body is made up of millions of cells that work together to allow normal if all the biological functions needed to keep it alive.
Even the cells grow old and should be replaced by new cells, cell reproduction is controlled by genes that are contained in the cell nucleus and which contain all the information necessary for life and reproduction of the cell and then the whole body They can be compared to a director and as such is closely monitoring the content and quality of the show: the genes directing and coordinating the activities of every cell in the body.
From birth we are under continuous attack by bacteria, toxins, pollutants that can harm the body but not only external agents, undermine our health, there may be problems from within. When cells divide may occur errors at the level of genes, these errors are called mutations and lead to malfunction and cell proliferation.
 
Cancer occurs when cells proliferate in an uncontrolled manner so as to determine the formation of tumor mass.

The immune system

The immune system is a set of cells and structures to identify, isolate, and destroy foreign invaders and mutated cells before they adversely affect the body.
These agents are recognized by the immune system through proteins called "antigens", expressed on the cell surface; special "receptor" expressed on cells of the immune system bind to antigen and this binding activates the immune response to destroy the cell in question.
The immune system is formed between the other by a network of lymph vessels that branch out in all parts of the body and inside which flows the sap that contains a population of white blood cells: lymphocytes.
Along the course of the lymphatic vessels are small bean-shaped organelles called lymph nodes.
The lymph nodes filter the lymph and then the bacteria, viruses and other pathogens are therefore removed from the circulation, in which process the lymph nodes may become enlarged and palpable.
 
Lymphocytes are white blood cells of a population of deputies to the defense against infections and cancer, are produced by the bone marrow, there are two types:

  • - B cells that mature into plasma cells that are deputies to the production of antibodies which can bind to foreign cells allowing for its removal.
  • - T lymphocytes that are activated when cells are infected directly destroy and also work by regulating the immune response.
  • The lymphocytes survived the elimination of the agent are transformed into memory cells that remain in the lymph nodes, ready to be reactivated when the body will be sent back to the same antigen.
 
What is Lymphoma?

Lymphoma is a type of cancer that can occur when an error occurs in the process of lymphocyte proliferation, abnormal cells can accumulate by two
 
mechanisms:


  • - Tose lymphoma cells replicate much more rapidly than normal cells
  • - Tose lymphoma cells have an average life greater than the normal cells.
  • Like normal cells, the lymphoma tose can proliferate in all districts of the body: the lymph nodes, bone marrow, spleen and organs extralymphatic.
There are two types of cancer of the lymphatic system:

a) Non-Hodgkin lymphoma
b) Hodgkin's disease
 
Non-Hodgkin's lymphoma

Is not a single disease but rather a group of closely related cancers that affect the lymphatic system.
Although different types of NHL have many features in common, differ in the microscopic appearance of cells, for how growth and development for the seat. The NHL is divided into two broad categories:
  • - NHL B-cell derived dall'anomalo development of B lymphocytes
  • - T-cell NHL arising dall'anomalo development of T lymphocytes
The NHL can occur in one or more lymph nodes, in lymphoid organs and specialized tissues situated in different lymphoid organs (Gastrointestinal, lung, etc.).. From the place of departure, the abnormal cells can spread through the vessels affecting multiple organs (systemic disease), or may remain localized (localized disease).
The exact causes of NHL are unknown, however, are indications of some risk factors:
  • - Exposure to chemicals (pesticides, fertilizers, solvents)
  • - Infection with Epstein Barr virus (causative agent of mononucleosis),
  • - Infection with HTLV viruses - 1
  • - HIV,
  • - Familiarity (not documented inheritance),
  • - Organ transplantation
in any case a final report has not been confirmed and it is said that when there are risk factors, we must necessarily contract the disease and vice versa.